TY - JOUR
AR - JBEM-2019-1-102
TI - Electrospun Nanofibrous Poly(3-Hydroxybutyrate-Co-3-Hydroxyvalerate) With Antibacterial Activity
AU -  Samir Abbad , Andaloussi
AU - Davy Louis , Versace
AU - Estelle , Renard
AU - Etienne , Dessauw
AU - Valerie , Langlois
JO - Journal of Biology Engineering and Medicine
PY - 2019
DA - Sat 17, Aug 2019
SN - 
DO - http://dx.doi.org/10.31487/j.JBEM.2019.01.02
UR - https://www.sciencerepository.org/electrospun-nanofibrous-poly-3-hydroxybutyrate-co-3-hydroxyvalerate-with-antibacterial-activity_JBEM-2019-1-102 
KW - poly (hydroxyalkanoate), PHBHV, electrospinning, antibacterial activity, antiradical property
AB - Elaboration of electrospun nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBHV)-based
mats was implemented through two routes to obtain antibacterial material containing carvacrol, a phenolic
compound extracted from essential oils. The first strategy relied on a direct blend of PHBHV and
carvacrol/-cyclodextrin inclusion complexes, PHBHV (carvCD-IC), while the second approach implied
the elaboration of multilayered scaffold via the introduction of poly(β-CD-epichlorohydrin), PolyCD. The
PolyCD/carv-based mat was electrospun between two hydrophobic PHBHV mats. Scanning Electron
Microscopy analysis of mats showed uniform and beadless fibers. The three layered materials [PHBHV-
(PolyCD/carv)-PHBHV] is sufficient to ensure optimal antiradical activity (RSA of 88.6%) and exhibit
interesting antibacterial activities against E. coli and S. aureus.