TY - JOUR AR - JBEM-2019-1-104 TI - Synthesis and Antimicrobial Activities of Containing Sulfur Heterocyclic Curcumin Derivatives AU - Dan, Wang AU - Dunjia, Wang AU - Heng, Lyu AU - Hengyi, Du AU - Lian, Cai JO - Journal of Biology Engineering and Medicine PY - 2019 DA - Tue 28, Jan 2020 SN - DO - http://dx.doi.org/10.31487/j.JBEM.2019.01.04 UR - https://www.sciencerepository.org/synthesis-and-antimicrobial-activities-of-containing-sulfur-heterocyclic_JBEM-2019-1-104 KW - Curcumins, sulfur heterocycle, synthesis, antimicrobial activity AB - Eight novel containing sulfur heterocyclic curcumins were synthesized and characterized by 1H-NMR, FTIR and MS spectroscopy. Their antimicrobial activities against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Aspergillus niger were also tested for MIC by using serial tube dilution method. The results showed that the antimicrobial activities of synthesized curcumin derivatives were better than curcumin. Especially, the compound 4-(1,3-dithiolan-2-ylidene)-1,7-di(thiophen-2-yl) hepta-1,6-diene-3,5- dione (2g) exhibited excellent the antimicrobial activities among these curcumin derivatives.