TY - JOUR
AR - JBN-2020-1-102
TI - Music and Dopamine – Potential in Movement Disorders
AU - Ichiro, Kawahata
AU - Kazuko , Hasegawa
AU - Ruriko, Kase
JO - Journal of Brain and Nerves
PY - 2020
DA - Tue 07, Apr 2020
SN - 2733-2284
DO - http://dx.doi.org/10.31487/j.JBN.2020.01.02
UR - https://www.sciencerepository.org/music-and-dopamine_JBN-2020-1-102 
KW - Parkinson’s disease, movement disorders, dopamine, tyrosine hydroxylase, ubiquitin-proteasome system, brain function, music, music therapy
AB - Most people have been deriving pleasure from music since long ago. Music is deeply associated with human
communication and language. Music had also been popular as therapy in early history. How can we feel
happiness or sadness when we listen to music? Scientifically, the dorsal and ventral striatum release
dopamine when listening to pleasurable music. The activity in these structures is known to associate with
the reward system of the human brain. Moreover, the nigrostriatal dopaminergic system regulates our motor
function, and this is the very part that is damaged in the movement disorders. In this article, we review the
potent role of music from the viewpoint of the dopaminergic system. We also describe the molecular
mechanism of the dopaminergic pathogenesis and suggest the potent ability of music for the therapy of
Parkinson's disease and related movement disorders.