TY - JOUR
AR - JICOA-2020-4-104
TI - Interaction between Statins and Omega 3 Poly-unsaturated Fatty Acids in Cardiovascular Disease: Synergistic or Not?
AU - Forel , Céline
AU - Messager , Laureen
AU - Sierra , Camille
AU - Contreras , Ivette
AU - Légère , Simon
AU - Pessiot-Royer , Solène
AU - Jean-Yves LE, GUENNEC
AU - Demion , Marie
JO - Journal of Integrative Cardiology Open Access
PY - 2020
DA - Fri 10, Jul 2020
SN - 2674-2489
DO - http://dx.doi.org/10.31487/j.JICOA.2020.04.04
UR - https://www.sciencerepository.org/interaction-between-statins-and-omega-3-poly-unsaturated-fatty-acids_JICOA-2020-4-104 
KW - Omega-3, PUFA, DHA, EPA, statin, cardiovascular disease, atherosclerosis, dyslipidemia, hypertriglyceridemia, coronary heart disease, n-3/n-6 ratio
AB - Up to the middle of the 2000’s, omega 3 polyunsaturated fatty acids were considered has having
cardioprotective properties. Patients having a myocardial infarction were supplemented with these
fatty acids in secondary prevention of myocardial infarction. Since then, many randomized clinical
trials failed to observe the cardioprotective effects previously described. The main hypothesis to
explain such change is the systematic prescription of statins to patients following a myocardial
infarction, statins interfering with the homeostasis of omega 3 fatty acids. This review discusses the
effects of different forms of omega-3 in association with statins on cardiovascular disease and
emphasize on the interaction between statins and omega 3 fatty acids leading to the possible need to
use higher dose of fatty acids to get a synergistic effect.