TY - JOUR
AR - JICOA-2021-1-101
TI - Value of miR-30d and miR-146a as Prognostic Biomarkers for Heart Failure Development Post Myocardial Infarction 
AU - Ana S., Holley
AU - Kirsty M. , Danielson
AU - Scott A. , Harding
AU - Peter D. , Larsen
JO - Journal of Integrative Cardiology Open Access
PY - 2021
DA - Wed 31, Mar 2021
SN - 2674-2489
DO - http://dx.doi.org/10.31487/j.JICOA.2021.01.01
UR - https://www.sciencerepository.org/value-of-mir-30d-and-mir-146a-as-prognostic-biomarkers_JICOA-2021-1-101 
KW - Acute myocardial infarction, inflammation, microRNA, biomarker, heart failure
AB - Introduction: The development of heart failure (HF) following an acute myocardial infarction (AMI) is
common and associated with poor clinical outcomes. In this context, the early identification of left
ventricular remodelling that ultimately leads to HF remains challenging, with current biomarkers
underperforming, and plasma microRNAs (miRs) have been proposed as functional biomarkers. Fibrotic
and inflammatory processes are implicated in pathogenic remodelling, and miR-30d and miR-146a are
reported to have regulatory function in these processes. This study aimed to determine if circulating levels
of these miRs could be early predictors of HF development post myocardial infarction.
Method: We conducted a case-control study with 46 AMI patients who developed HF within 1 year (cases)
matched with control AMI patients (1:2 ratio) who did not develop HF and measured plasma miRs via
quantitative reverse transcription polymerase chain reaction.
Results: miR-30d was significantly upregulated in cases compared to controls (p<0.05), whereas miR-146a
was not significantly different (p=0.57). ROC curve analysis for miR-30d demonstrated a modest sensitivity
and specificity for this prediction (AUC=0.61, p<0.05). However, once adjusted for confounding factors
such as atrial fibrillation and markers of inflammation, miR-30d was not found to be independently
associated with HF development post myocardial infarction (OR 1.12 95% CI 0.99-1.27, p=0.08).
Conclusion: miR-30d and markers of inflammation were significantly elevated in patients who developed
HF within 1 year of their AMI. Further research is needed to determine the regulatory role that miR-30d
may play in HF and the utility it may have as a prognostic marker in this setting.