TY - JOUR
AR - JSO-2020-4-108
TI - A Comprehensive Expression Profile of tRNA-Derived Fragments in Papillary Thyroid Cancer
AU - Shiting , Shan
AU - Yuting , Wang
AU - Chunfu, Zhu
JO - Journal of Surgical Oncology
PY - 2020
DA - Fri 28, Aug 2020
SN - 2674-3000
DO - http://dx.doi.org/10.31487/j.JSO.2020.04.08
UR - https://www.sciencerepository.org/a-comprehensive-expression-profile-of-trna-derived-fragments-in_JSO-2020-4-108 
KW - Papillary thyroid cancer, tRNA-derived fragments, expression profile
AB - Objective: In recent years, the incidence of thyroid cancer has been increasing. Papillary thyroid cancer
(PTC) is the most common type of malignant thyroid tumor, accounting for approximately 85% of thyroid
cancer cases. Although the genetic background of PTC has been studied extensively, relatively little is
known about the role of small non-coding RNA (sncRNA) in this disease. tRNA-derived fragments (tRFs)
represent a newly discovered class of sncRNAs that exist in many species and play a role in many biological
processes.
Methods: In this study, we used RNA sequencing to analyse the expression of tRFs in fresh frozen
specimens from PTC tissues and normal tissues adjacent to the tumors. Through this analysis, we identified
49 unique tRFs and transfer RNA halves and then performed quantitative PCR to determine the expression
levels of these molecules and to make bioinformatic predictions.
Conclusion: In this report, we provide a comprehensive catalog of tRFs in PTC and assess the abnormal
expression of these fragments. These preliminary findings can be used as the basis for further research
regarding the functional role of tRFs in patients with PTC.