TY - JOUR
AR - NNB-2020-2-102
TI - Central Genesis of Dysrhythmia
AU - Alberico , Marielisa
AU - Bellizzi , Annamaria
AU - Benigni , Giovanni
AU - Botticella , Filomena
AU - C.A. , Tammaro
AU - Capaldo , Guglielmo
AU - Corbo , Antonio
AU - Corbo , Giulia
AU - De Caro , Monica
AU - Dragonetti , Carmela
AU - Ferrara , Maurizio
AU - Fiori, Patrizia
AU - Gennaro , Bellizzi
AU - Gizzi , Raffaele
AU - Guerriero , Barbara
AU - Iorillo ,  Luigi
AU - L.M. , Giannetti
AU - Manganelli , Gianvito
AU - Massarelli , Marco
AU - Mazza , Emerico
AU - Minichiello , Stefania
AU - Monaco , Antonio
AU - Morella , Alessandro
AU - Pace , Erminio
AU - Pellecchia , Vincenzo
AU - Pelosi , Chiara
AU - Savino , Patrizia
JO - Neurology and Neurobiology
PY - 2020
DA - Wed 29, Apr 2020
SN - 2613-7828
DO - http://dx.doi.org/10.31487/j.NNB.2020.02.02
UR - https://www.sciencerepository.org/central-genesis-of-dysrhythmia_NNB-2020-2-102 
KW - Acute ischaemic syndromes, chronic cerebro-vascular diseases, cardiovascular reactivity, cardiac biomarkers, glycosylated haemoglobin, inflammatory parameters
AB - Introduction: The central nervous system is the generator of the dynamic balance between cholinergic and
noradrenergic activity. Different behavioral tendencies are observed in subjects with prevalent parasympatic
tone (defense strategy, energy sparing, dissociation) compared to those with sympathic one (relational
interaction, high energy expenditure). These responses may influence susceptibility and vulnerability to
diseases. The aim of our study was to examine cardiovascular function from the heart to the periphery by
24 hours detection of both heart and pulse rate in cerebrovascular conditions.
Materials and Methods: We recruited 113 Acute Ischaemic Syndromes (AIS, age 73,43 sd 12,34), 32
Chronic Cerebro-Vascular Diseases (CCVD, age 75,95 sd 8,06), 30 Other Neurological Diseases (OND,
age 50,09 sd 15,05). Cardiovascular reactivity (CR) was defined by beat indices, ratio (R) or difference (D)
between higher maximal or minimal heart rate (HR) on higher maximal or minimal pulse rate (PR). A value
< 1 or > 1 were considered as negative (NCR) or positive CR (PCR), respectively.
Results: Max PR was significantly higher in CCVD and AIS compared to OND. Max CR was lower in
CCVD and AIS compared to OND. Increased levels of glycosylated hemoglobin, cardiac biomarkers,
abnormal findings at Holter ECG and Echocardiography were particularly observed in case of NCR.
Conclusions: NCR may interfere with normal activity of daily living. Higher Hachinski ischaemic scores
in these patients point out a higher ischaemic load. Moreover, NCR identified a category of acute patients
with worst outcomes, requiring prompt intensive care because of higher risk of complications and mortality.
Our observations may be useful for better choosing among therapeutical options, planning rehabilitation
and health enhancing physical activity in aging. Moreover, they may reduce the risk of injuries for training
overload in athletes.