TY - JOUR
AR - NNB-2020-2-110
TI - From Neuroinflammation to Neuroprotection: Focus on Potential New Therapeutic Targets in Cognitive Impairment
AU - Antonino Maria , Cotroneo
AU - Pietro, Gareri
AU - Valeria Graziella , Laura Manfredi
JO - Neurology and Neurobiology
PY - 2020
DA - Sat 30, May 2020
SN - 2613-7828
DO - http://dx.doi.org/10.31487/j.NNB.2020.02.10
UR - https://www.sciencerepository.org/from-neuroinflammation-to-neuroprotection-focus-on-potential-new-therapeutic-targets-in-cognitive-impairment_NNB-2020-2-110 
KW - Neuroinflammation, neuroprotection, cholinergic precursors
AB - Neurodegeneration is closely linked to neuroinflammation. It is often associated with oxidative stress and
meaningful changes in cell energy metabolism. Neuroinflammation is due to non-neuronal cell activation
(microglia, astrocytes, mast cells) activation and proliferation. Also, it is associated with pro-inflammatory
substances release, able to modify synaptic plasticity. Microglia and astrocytes activation lead to toxic
agent’s release (reactive oxygen species, inflammatory cytokines); however, the final target of this process
is the cholinergic neuron. A number of substances can promote neuroprotection; recent scientific evidence
focuses on the role of sirtuins. In particular, SIRT1 is activated by caloric restriction, NAD biosynthesis and
different activators, called STACs (Sirtuin Activating Compounds). Citicoline is one of the most powerful
STACs. It has been widely shown to possess neuroprotective action, and lots of studies strengthened its
possible role.