TY - JOUR
AR - PDR-2020-2-104
TI - Depressive Disorders and Incidence of COVID-19: Is There a Correlation and Management Interference?
AU - Nagwa , Ali Sabri
AU - Mohamed , Ahmed Raslan
AU - Eslam , Mansour Shehata
AU - Sara , Ahmed Raslan
JO - Psychological Disorders and Research
PY - 2020
DA - Thu 24, Sep 2020
SN - 2674-2470
DO - http://dx.doi.org/10.31487/j.PDR.2020.02.04
UR - https://www.sciencerepository.org/depressive-disorders-and-incidence-of-covid-19-is-there-a-correlation_PDR-2020-2-104 
KW - COVID-19, depression, SSRIs, antidepressants, direct acting antivirals
AB - Corona virus Disease-2019 is a new strain of Coronaviruses (COVID-19) causing an infection which has
rapidly spread all over the Globe, where the primary pathways of infection spreading reported to be through
large respiratory droplets and the disease severity has varied from mild self-limiting flu like illness to acute
pneumonia, respiratory collapse and death. On the other hand, depression is a disease that could be progress
to a life-threatening condition that affects globally hundreds of millions of people. The aim of this review
is desired to investigate and find a correlation between depressive disorders and the incidence of COVID19, where, pathogeneses of depressive disorder and its effect on the immunity system was addressed, besides
the impact of depression on individual food intake and its complications regarding weight gain, insulin
resistance, and immune system disruption was also discussed which by turn might increase the risk for
infection with COVID-19. Finally, the possible drug-drug interactions between drugs included in
management protocols of both depressive disorder including antidepressants and anxiolytics and COVID19 with possible proposed alternatives.