TY - JOUR
AR - RCO-2018-1-102
TI - High-intensity focused ultrasound as an effective and safe treatment for palliation of pain related to pancreatic cancer
AU - Li, LI
AU - Wei, MAO
AU - Kun , ZHAO
AU - Min , YUAN
AU - Qing , XU
AU - Yi , YU
AU - Zhong, zheng ZHU
JO - Radiotherapy and Clinical Oncology
PY - 2018
DA - Fri 05, Oct 2018
SN - 2674-2497
DO - http://dx.doi.org/10.31487/j.RCO.2018.01.002
UR - https://www.sciencerepository.org/high-intensity-focused-ultrasound-as-an-effective-and-safe-treatment-for-palliation-of-pain-related-to-pancreatic-cancer_RCO-1-102 
KW - Cancer-related pain, high-intensity focused ultrasound, pain relief, pancreatic cancer
AB - This study was to evaluate the efficacy and safety of high intensity focused ultrasound (HIFU) in pain
palliation of advanced unresectable pancreatic cancer. Twelve patients suffering cancer-related pain were
treated with HIFU, and one case was treated a second time. The type and dose of analgesic drugs were
obtained at baseline and during 12-week follow-up and converted to daily oral morphine dose. Post-HIFU
pain relief, tumor ablation ratio, tumor reduction ratio in maximal tumor diameter, and adverse events were
assessed. Pain was relieved in 11 cases (84.6%), with equal morphine dose reduction ratio from 23% to
100%. Complete pain relief was observed in 4 patients (30.8%), a partial pain relief was observed in 7
patients (53.8%), and no improvement of pain was observed in 2 patients (15.4%). Both tumor ablation ratio
(P = 0.175) and tumor reduction in maximal diameter (P = 0.532) were not significantly associated with the
reduction ratio of equal morphine dose. There were no severe adverse events related to HIFU therapy seen
in any of the patients treated. Our data suggested that HIFU is an effective and safe treatment modality for
palliation of the pain related to pancreatic cancer.