TY - JOUR
AR - RCO-2021-1-102
TI - Primary and Secondary Angiosarcoma of the Breast: Report of Two Cases and Review of the Literature
AU - Uriel Norberto, Rivas-Mendoza
AU - Cristóbal, Calixto-Martínez
AU - Raquel , Valencia-Cedillo
AU - Jaime , Resendiz-Colosia
AU - Jesús Alberto , Sansón-Riofrio
JO - Radiotherapy and Clinical Oncology
PY - 2021
DA - Wed 14, Apr 2021
SN - 2674-2497
DO - http://dx.doi.org/10.31487/j.RCO.2021.01.02
UR - https://www.sciencerepository.org/primary-and-secondary-angiosarcoma-of-the-breast-report-of-two_RCO-2021-1-102 
KW - Angiosarcoma, breast, primary, secondary, breast sarcoma
AB - Introduction: The breast's angiosarcoma is a rare entity, representing 1% of the breast's malignant neoplasms and is classified as primary and secondary; the latter is associated with radiotherapy and chronic lymphedema. Clinically both present as a voluminous and rapidly growing lesion. Surgery is the cornerstone of a treatment since it provides the most outstanding local control, whereas radiotherapy and chemotherapy have little impact on the disease. Similarly, the oncological prognosis is poor because this type of tumor has a high recurrence rate and overall, 5-year survival of only 20%.
Objective: Two cases of angiosarcoma of the breast (primary and secondary) are reported, both treated in the Breast Tumor Service and a bibliographic review of the disease is presented.
Materials and Methods: All breast cancer cases were reviewed in the Breast Tumor Service for two years.
Results: In the first clinical case, a 61-year-old patient was presented with a 5-month-old primary angiosarcoma in the right breast, treated with modified radical mastectomy. While in the second case, the clinical history of a 76-year-old woman with secondary breast angiosarcoma is related; the patient had a history of right breast cancer, treated ten years previously with conservative surgery, sentinel node and adjuvant radiotherapy. However, the woman presented local recurrence six years later, and she was operated on with a total mastectomy. Three years later, she developed an angiosarcoma in the surgical bed that warranted a wide resection of the chest wall.
Conclusion: The breast's angiosarcoma is an aggressive and rare tumor of unknown aetiology, since it has a high recurrence rate and poor survival. Its main prognostic factors are tumor volume and resection margins. Therefore, early diagnosis is essential because it allows complete resection of the lesion.