TY - JOUR
AR - RGM-2018-1-101
TI - Systematic investigation of a new nanoscale bioactive glass on wound healing in vivo in comparison with the clinically applied 45S5 Bioglass
AU - Jianhua , Shen
AU - Weizhong, Gu
AU - Xianyan , Yang
AU - Yunling, Li
AU - Zhongru , Gou
AU - Zhouwen, Jin
JO - International Journal of Regenerative Medicine
PY - 2018
DA - Tue 10, Apr 2018
SN - 2613-5914
DO - http://dx.doi.org/10.31487/j.RGM.2018.10.001
UR - https://www.sciencerepository.org/systematic-investigation-of-a-new-nanoscale-bioactive-glass-on-wound-healing-in-vivo-in-comparison-with-the-clinically-applied-45S5-Bioglass_RGM-1-101 
KW - Nanoscale bioactive glass, 45s5 Bioglass@, Boron, Zinc, wound healing
AB - Aim: Recently, bioactive glass (BG)-based inorganic biomaterials which differ from polymer wound
dressings have become a promising candidate favorable for improving acute wound healing and even some
chronic, non-healing wound repair. We developed a new sol–gel-derived BG (Sol-nBG) nanomaterial and
evaluated its biological efficacy on wound healing based on the antibacterial and wound-healing
accelerating potentials of the specific trace elements in the chemical composition of Sol-nBG.
Materials and methods: The sol-nBG powder was prepared by a facile sol–gel route which readily resulted
in nanoscale particles after undergoing a low-heat calcination process. The amorphous nature of the SolnBG powder was confirmed by X-ray diffraction analysis, and the biologically-active ions such as calcium,
silicon, zinc, and boron could be rapidly released in Tris buffer, similar to the orthopedically and dentally
available 45S5 Bioglass@ (45S5 BG). In particular, the Sol-nBG and 45S5 BG particles were well tolerated
by the surrounding host wound tissue without causing any chronic inflammation, and appreciably enhanced
the wound healing of a deep second-degree scald.
Results and Conclusions: The results showed that the Sol-nBG significantly promoted wound healing with
increased epidermal and dermal regeneration and collagen deposition in comparison with the 45S5 BG or
control treatment. Therefore, it is reasonable to consider that the new Sol-nBG facilitates wound treatment
and is a promising candidate for wound healing in future.