TY - JOUR
AR - RGM-2019-1-101
TI - Mechanical properties of 3D bioprinted dermis: characterization and improvement
AU - Amélie , Thépot
AU - Christophe A. , Marquette
AU - Edwin J. , Courtial
AU - Marion , Albouy
AU - Mélissa , Dussoyer
AU - Morgan Dos , Santos
JO - International Journal of Regenerative Medicine
PY - 2019
DA - Wed 30, Jan 2019
SN - 2613-5914
DO - http://dx.doi.org/10.31487/j.RGM.2019.01.001
UR - https://www.sciencerepository.org/mechanical-properties-of-3D-bioprinted-dermis-characterization-and-improvement_RGM-2019-1-101 
KW - Bioprinting, collagen I, dermis, fibrillin I, mechanobiology, skin.
AB - Bioprinting is a promising way to create native-equivalent tissues for skin replacement in several
pathologies and trauma. These last few years, various constructs have been reported, composed of
fibroblasts and keratinocytes used to recapitulate the dermo-epidermal structure. However, the ability to
control and characterize the mechanical properties of such constructs is a critical point to insure the transfer
of these engineered products to clinic in a near future. In the present study, we had investigated the
modulation of the biomechanics of a bioprinted dermis model through physical constrain during tissue
maturation. Two passive tension devices were then designed and tested to mature the tissue after printing.
Decrease in tissue retraction and increase of collagen I densities, associated to modulations of Young’s
modulus were obtained after 20 days of tissue maturation. Taken together, these results attest for the first
time in literature of promising methods to modulate the mechanical properties of bioprinted skin models.