TY - JOUR
AR - RGM-2020-1-104
TI - Influence of Chitosan or Keratin on Titanium Implant Surface - A Systematic Review
AU - Eliza, Ranjit
AU - Ajay , Sharma
AU - Stephen , Hamlet
AU - Roy , George
AU - Robert , Love
JO - International Journal of Regenerative Medicine
PY - 2020
DA - Thu 28, May 2020
SN - 2613-5914
DO - http://dx.doi.org/10.31487/j.RGM.2020.01.04
UR - https://www.sciencerepository.org/influence-of-chitosan-or-keratin-on-titanium-implant-surface-a-systematic-review_RGM-2020-1-104 
KW - Chitosan, Hydrogel, Implant, Keratin, Osseointegration
AB - Purpose: This systematic review was carried out to investigate the effects of keratin and chitosan hydrogel
preparations on dental implant osseointegration.
Materials and Methods: The electronic search was conducted on five databases: Scopus, EBSCOhost
MEDLINE, EBSCOhost Dentistry and Oral Science, PubMed, and Web of Science. Studies that determined
the in vitro or in vivo efficacy of keratin and chitosan hydrogel on osseointegration were included in the
review.
Results: Of the 760 studies initially gathered, nine met the inclusion criteria. These studies demonstrated
that dental implants coated with keratin and chitosan hydrogels resulted in improved biological properties.
It was also concluded that the inclusion of chitosan in keratin hydrogels improves the mechanical strength
and helps increase durability through ameliorating degradation and swelling characters. Both the polymers
increased bone-implant contact and new bone formation in animal models.
Conclusion: This systematic review demonstrates that keratin and chitosan hydrogel, is effective in
initiating osteogenesis, reinforcing the currently available evidence that these polymers could be a substrate
in dental implant treatment.