TY - JOUR
AR - RGM-2020-2-101
TI - Autologous Adipose-Derived Stem Cells, Platelet-Rich Plasma, and Fibrin Enhance Healing of Mandibular Bone Defects in Swine
AU - Aaron J. , Maki
AU - Anna C. , Ercolin
AU - Jamey J. , Cooper
AU - Kelly S. , Roballo
AU - Marcello , Rubessa
AU - Matthew B., Wheeler
AU - Rathnaweera A.C. , Rabel
JO - International Journal of Regenerative Medicine
PY - 2020
DA - Thu 18, Jun 2020
SN - 2613-5914
DO - http://dx.doi.org/10.31487/j.RGM.2020.02.01
UR - https://www.sciencerepository.org/autologous-adipose-derived-stem-cells-platelet-rich-plasma-and-fibrin_RGM-2020-2-101 
KW - ASC, bone regeneration, fibrin, platelet-rich plasma, mandible, porcine
AB - The primary aim of this study was to assess the therapeutic effects of autologous platelet-rich plasma and
fibrin scaffolds combined with autologous adipose stem cells (ASCs) for critical-size defects in the pig
mandible. Fibrin scaffolds supplemented with calcium hydrogen phosphate and platelet-derived growth
factors were hypothesized to accelerate healing in porcine mandible bone compared to ASC-only injections
and untreated controls. Three treatments included the use of autologous ASCs from liposuction with the
addition of platelet-rich plasma, fibrin scaffolds, or as cell-only controls. All three treatments using ASCs
were determined to increase bone mineral density and bone volume fraction compared to untreated controls.
In general, the addition of both platelet-rich plasma and fibrin scaffolds to autologous ASCs from
liposuction improved bone healing of critical-size defects.