TY - JOUR
AR - SCR-2020-9-115
TI - Lynch Syndrome and Breast Cancer: Case Reports and Literature Review
AU - Spyridon , Marinopoulos
AU - Eleni , Papamattheou
AU - Sofia-Dionysia , Touriki
AU - Aris , Giannos
AU - Constantine , Dimitrakakis
JO - Surgical Case Reports
PY - 2020
DA - Wed 23, Sep 2020
SN - 2613-5965
DO - http://dx.doi.org/10.31487/j.SCR.2020.09.15
UR - https://www.sciencerepository.org/lynch-syndrome-and-breast-cancer-case-reports-and-literature-review_SCR-2020-9-115 
KW - Breast cancer, Lynch syndrome, genetic testing
AB - In the era of advanced cancer genomics, our knowledge of hereditary cancer mutations continues to expand.
Lynch syndrome is one of the hereditary cancer predisposition syndromes associated with an increased
lifelong risk of several types of cancer development, such as colorectal, endometrial, ovarian and other. This
unique syndrome is an autosomal dominant inherited disease caused by mutations on EPCAM gene or on
mismatch repair genes, which lead to microsatellite instability. In this article we will present three such
cases visiting our clinic. They had breast cancer and a familial or personal history of malignancy. This article
summarizes what we consider important about Lynch syndrome and breast cancer.