TY - JOUR
AR - SCR-2021-2-102
TI - Risk Factors of Survival in Dedifferentiated Liposarcoma
AU - Kevin , Nguyen
AU - Jonathan , Gootee
AU - Sarah , Aurit
AU - Sara , Albagoush
AU - Christina, Curtin
AU - Peter , Silberstein
JO - Surgical Case Reports
PY - 2021
DA - Tue 02, Feb 2021
SN - 2613-5965
DO - http://dx.doi.org/10.31487/j.SCR.2021.02.02
UR - https://www.sciencerepository.org/risk-factors-of-survival-in-dedifferentiated-liposarcoma_SCR-2021-2-102 
KW -  Dedifferentiated liposarcoma, surgical margins, retroperitoneum, survivorship, National Cancer Database
AB - Background: Liposarcoma is the most common malignant soft tissue sarcoma for which surgical resection
is the most utilized therapeutic option. In this study, we aimed to explore the associations of surgical margins
among other risk factors on survival in patients with dedifferentiated liposarcoma.
Patients and Methods: The National Cancer Database (NCDB) was used to select patients with
dedifferentiated liposarcoma to determine if surgical margins were associated with worse overall survival
after controlling for age, gender, race, Charlson-Deyo score, anatomic site, treatment approach, tumor size,
tumor grade, and presence of metastases through multivariable analysis.
Results: Multivariable analyses showed that mortality risk increased for dedifferentiated liposarcoma
patients with the following: older age, male, metastasis, high tumor grade, macroscopic residual tumor
compared to no residual tumor.
Conclusion: Older age, male sex, presence of metastasis, retroperitoneal/abdomen primary site, high grade
tumors, and macroscopic residual tumor present after surgery led to an increased risk of mortality.