TY - JOUR
AR - TCR-2020-1-101
TI - Concomitant Thrombotic Microangiopathy and Rejection in a Recent Kidney Transplant: A Case Study
AU - Abdulaziz, Al-Thumali
AU - El-Sadig Yousif, 
AU - Muhammad A., Bukhari
AU - Najla K, Almalki
AU - Rayan, Magrabi
JO - Transplantation Case Reports
PY - 2020
DA - Fri 31, Jan 2020
SN - 2733-2527
DO - http://dx.doi.org/10.31487/j.TCR.2020.01.01
UR - https://www.sciencerepository.org/concomitant-thrombotic-microangiopathy-and-rejection-in-a-recent-kidney-transplant_TCR-2020-1-101 
KW - Thrombotic microangiopathy, antibody-mediated rejection, transplantation rejection, kidney transplantation, renal allograft
AB - Thrombotic microangiopathy (TMA) is an uncommon, life-threatening complication that adversely affects
kidney transplant recipient and allograft survival. Post-transplantation TMA can occur as recurrence of the
primary TMA or as a de novo condition. The latter can be triggered by numerous factors post-transplantation
including calcineurin inhibitors, certain infections and antibody-mediated rejection. Rejection-associated
TMAs carry a significantly lower graft survival rate compared with post-transplant TMAs that are not
associated with rejection. In this case report, we present a rare case of rejection-associated TMA in a recently
transplanted renal allograft that was managed in Al-Hada Armed Forces Hospital. Despite the poor expected
outcome of this condition; the patient was successfully treated after early initiation of medical interventions.
Transplantation teams may face many challenges managing such a combination of medical conditions,
which may halt pursuing appropriate diagnostic and therapeutic measures in a timely fashion. This article
highlights some of these challenges for better understanding of such a complex condition.