Abdirahaman Nuno,Mokhtar Eltair,T. A. Agarwal, Damage Control Laparotomy for Severe Typhoid Fever: A Case Report American Journal of Surgical Case Reports 2020 2674-5046 http://dx.doi.org/10.31487/j.AJSCR.2020.03.07 https://www.sciencerepository.org/damage-control-laparotomy-for-severe-typhoid-fever-a-case-report_AJSCR-2020-3-107 Abstract: Persistent intra-abdominal sepsis is a challenging complication of abdominal typhoid with a high mortality and difficult to manage. Delayed perforations following initial operative intervention is one of the rarer complications of this disease, causing wound breakdown and open abdomen, resulting in fistula. We present the management of a rare case, which presented with multiple perforations and multiple organ system dysfunction then complicated post-operatively with multiple fistula and open abdomen. Keywords: Abdominal typhoid, fistula, sepsis, laparostomy, damage control laparotomy