Maria Helena Bellini,Silva JPL ,Teixeira LF ,
[6]-Gingerol Decreases Clonogenicity And Radioresistance of Human Prostate Cancer Cells
Clinical Oncology and Research
2019
2613-4942
http://dx.doi.org/10.31487/j.COR.2019.05.07
https://www.sciencerepository.org/6-gingerol-decreases-clonogenicity-and-radioresistance-of-human-prostate-cancer-cells_COR-2019-5-107 
Abstract: The phenolic compound [6]-Gingerol, isolated from Zingiber officinale, has been demonstrated to have
antitumor activity for different types of malignant tumours. Prostate cancer is the most common malignancy
among males worldwide, being the second leading cause of cancer death in men. In the present study, we
investigated the antitumor action of [6]-Gingerol on a human prostate cancer cell line (LNCaP). Our data
shows that [6]-Gingerol treatment induced a dose-dependent decrease in the cell viability. Compared with
the vehicle control, the cell viabilities were 79.90 ± 3.56% and 53.06 ± 7.82% when the LNCaP cells were
exposed to 150 μg/mL and 300 μg/mL of [6]-Gingerol, respectively. The treatment of LNCaP with 300 µM
of [6]-Gingerol led to a significant reduction (~25%) on the clonogenic survival of these cells. Furthermore,
[6]-gingerol acted as a radiosensitizer for LNCaP cells. The pretreatment of these cells with [6]-Gingerol
significantly enhanced the killing effects of ionizing radiation with a dose enhancement ratio of 1.25. Our
results demonstrate the anti-tumour activities of [6]-Gingerol. Further studies are needed to elucidate the
mechanisms involved.Keywords: Prostate cancer, [6]-Gingerol, cell viability, clonogenicity, radiosensitizer