Heikki Joensuu,Mikael Eriksson,
Mitotic Count and Estimation of the Risk of GIST Recurrence in Patients Treated with Preoperative Imatinib
Clinical Oncology and Research
2019
2613-4942
http://dx.doi.org/10.31487/j.COR.2019.5.15
https://www.sciencerepository.org/mitotic-count-and-estimation-of-the-risk-of-gist-recurrence_COR-2019-5-115 
Abstract: Preoperative imatinib is used frequently in the treatment of large localized GISTs to shrink the tumor prior
to surgery. This approach may lead to challenges in the estimation of the risk of recurrence and the need
of adjuvant imatinib, because the diagnosis is usually made from a needle biopsy with scant tissue for the
assessment of GIST mitotic activity, a key prognostic factor. We propose a mitosis count multiplication
method as a proxy for estimating the tumor mitotic count in select cases.
Keywords: GIST, imatinib, neoadjuvant therapy, adjuvant therapy, risk prediction