Basappa .,Dinesh  Rangappa,K.N.  Thanuja,Kanchugarakoppal S.  Rangappa,M. Navya  Rani,Toreshetahally R.  Swaroop,
Synthesis, Characterization and Cytotoxic Studies of Benzamide Derivatives of Anacardic Acid using Human Liver Cancer Cells
Clinical Oncology and Research
2020
2613-4942
http://dx.doi.org/10.31487/j.COR.2020.04.07
https://www.sciencerepository.org/synthesis-characterization-and-cytotoxic-studies-of-benzamide-derivatives_COR-2020-4-107 
Abstract: Naturally occurring anacardic acid based benzamides were reported to show anti-inflammatory and
anticancer activities, where we synthesized and characterized by NMR and HRMS analysis and also tested
a series of anacardic acid based benzamides and evaluated against the proliferation of human liver cancer
cells (HepG2). Among the tested compounds, 6j-m showed good inhibitory activity against HepG2 cells
with IC50 values ranging from 78.2-91.9 μM. In conclusion, we herein reported the newer series of an
academic acid benzamides for the first time.Keywords: Anacardic acid, cytotoxic, HepG2, benzamid