Aisling Farrell,Farrell  SA,Henry  MT,Kennedy  MP,
Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma- A Single Center Review of the Diagnostic Approach
Clinical Oncology and Research
2020
2613-4942
http://dx.doi.org/10.31487/j.COR.2020.06.06
https://www.sciencerepository.org/pulmonary-mucosa-associated-lymphoid-tissue-lymphoma-a-single-center-review_COR-2020-6-106 
Abstract: Pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma is a rare disease, and diagnosis is
difficult, often requiring multiple attempts at tissue sampling. The aim of this review was to evaluate the
diagnostic pathway. A retrospective review was performed of patients diagnosed with pulmonary MALT
lymphoma in a tertiary referral lung cancer center over 9 years. Ten patients were identified, and each
diagnostic and treatment approach was analysed. 30% were diagnosed via transbronchial biopsy, two with
the assistance of radial probe ultrasound guidance and one with transbronchial lung cryobiopsy of a
predetermined CT-guided targeted segment. 70% were diagnosed following surgical biopsy. 40% had
localized disease. The diagnosis was not successfully achieved until a large-sized tissue specimen was
obtained. The implementation of novel bronchoscopy techniques can assist in reducing the number of
invasive surgical procedures required to obtain a diagnosis. All cases should be discussed in a
multidisciplinary setting prior to diagnostic attempts.
Keywords: Lung cancer, bronchoalveolar lavage, cryobiopsy, MALT, transbronchial biopsy