Lucía Martínez  Cuesta,Pamela  A Lendez,Maureen  A Sheahan,Raymond  RR Rowland,Maria Victoria  Nieto Farias,Guillermina  L Dolcini,Maria Carolina  Ceriani,
Bovine Leukemia Virus Non-Productive Infection of Human Mammary Epithelial Cells (MCF10A)
Clinical Oncology and Research
2020
2613-4942
http://dx.doi.org/10.31487/j.COR.2020.09.03
https://www.sciencerepository.org/bovine-leukemia-virus-non-productive-infection-of-human-mammary_COR-2020-9-103 
Abstract: Bovine leukemia virus (BLV) is a retrovirus that causes lymphosarcoma in cattle. Some researchers suggest
that BLV could be related to breast cancer development, however, evidence that the virus can infect the
human counterpart is lacking. For that reason, the objective of this study was to infect in vitro a human
mammary epithelial cell line (MCF10A) with BLV. The results suggest that the infection is non-productive,
since only a fragment of the viral gene pol was detected in the cellular DNA. These results are consistent
with previous studies, where fragments of different BLV genes were found in human mammary tissue.
Future studies should investigate whether this non-productive infection can be associated with human breast cancer.Keywords:  Bovine leukemia virus, breast cancer, infections