Eman H. Bakr,Hanan M. Ghoneim,Omima Tharwat,
The Relationship between Serum Levels of Anti-Mullerian Hormone and Body Mass Index in Adolescents with Polycystic Ovary Syndrome
Case Reports in Obstetrics Gynecology and Reproductive
2019
2674-5070
http://dx.doi.org/10.31487/j.CROGR.2019.01.02
https://www.sciencerepository.org/the-relationship-between-serum-levels-of-anti-mullerian-hormone_CROGR-2019-1-102 
Abstract: Introduction: Polycystic ovary syndrome is widely prevalent among adolescents and early diagnosis is
crucial. While accurate diagnosis is not straightforward, anti-Mullerian hormone was found to be a reliable
marker among young patients with polycystic ovary syndrome. However, its serum level was found to be
affected by many other variables. This study assessed the relation between serum levels of anti-Mullerian
hormone and body mass index in adolescents with polycystic ovary syndrome.
Methods: This was a cross sectional analytical study, conducted at the Gynecology and Obstetrics
outpatient clinics at Suez Canal University hospitals in Ismailia. It included 100 adolescents with PCOS
who fulfilled the revised Rotterdam diagnostic criteria for PCOS, attending secondary stage or higher levels
of education in Ismailia, Egypt. The recruited patients were divided into two groups. Group one reported to
have BMI ≥ 30 and group two included those who have BMI < 30. Complete history taking, clinical
examination (BMI) and biochemical markers including assessment of serum LH and AMH level, and
ultrasound assessment to detect ovarian volume, antral follicular count, and presence of ovarian cysts.
Results: AMH levels were not affected by BMI in adolescent patients with PCOS (r 0.19, p value 0.185).
There were significant correlations between serum AMH and LH level, & between AMH and ovarian
morphology among the studied population. The AMH was higher among those with menstrual irregularity
and those with hyper-androginism. Accordingly, AMH level is not affected by patients' weight.
Conclusion: The AMH was correlated to clinical and biochemical findings of PCOS.Keywords: PCOS, polycystic ovary syndrome, anti-Mullerian hormone, AMH, LH, ovarian morphology, adolescents