Ignác Capek,
Novel Composite Nanocarriers
Global Drugs and Therapeutics
2020
2733-256X
http://dx.doi.org/10.31487/j.GDT.2020.01.02
https://www.sciencerepository.org/novel-composite-nanocarriers_GDT-2020-1-102 
Abstract: Need for materials with high biocompatible properties have led to the development of prodrug-decorated
nanoparticles. The structure of present nanostructures consists of the hydrophobic core and hydrophilic
shell. The shell acts as an external envelop which enhances the colloidal stability of dispersion which
protects the prodrug of the nanoparticles from photo- and thermal-initiated degradation. The composite
nanoparticles coated by organic shells with functional groups were considered to govern the covalent
immobilization of therapeutics/biomolecules. The nanoparticles with unique physiochemical properties may
be useful as biosensors in living whole cells. The enhanced cellular drug delivery to cancer cell lines via
nanoconjugates revealed that smart nanoparticles are an effective tool for transporting and delivering drugs.Keywords: Polymer-and silica-based nanoparticles, biodecorated nanoparticles, cancer, drug delivery, therapeutics