Christopher L. Axelrod ,Emily Kullman,Kathleen D. Little ,Kenneth E. Sparks ,
Menopausal Status Impairs Acute Inflammatory Recovery from Resistance Exercise
Gerontology and Geriatric Research
2020
2733-2292
http://dx.doi.org/10.31487/j.GGR.2020.01.04
https://www.sciencerepository.org/menopausal-status-impairs-acute_GGR-2020-1-104 
Abstract: The purpose of this study was to explore the effects of menopausal status on inflammatory responses to a
single bout of resistance exercise (RE). Twenty pre- (N=10) or post- menopausal (N=10) women aged 18-
65 years had one repetition maximum (1RM) determined for the chest and leg press, leg and biceps curl,
vertical pull down, triceps and leg extension exercises. On a separate day, participants completed a session
of full body resistance exercise (RE) during which subjects performed three sets of 10 repetitions at 75%
1RM for the aforementioned exercises. Blood samples were obtained prior to, immediately, and one hour
after exercise. Changes in interleukin-6, -10, and transforming growth factor beta (IL-6, -10, and TGF-β1)
were determined via enzyme-linked immunosorbent assays (ELISA). IL-6 significantly increased (P<0.05)
over time in both groups. Immediately post exercise levels of IL-10 were significantly lower (P<0.05) in
the post-menopausal group. Changes in IL-10 correlated with 17β-estradiol levels (r2=0.45, P<0.001).
Menopausal status impaired inflammatory recovery following acute RE. These changes may be attributed
to menopause-induced perturbations to the hormonal milieu. Keywords: Cytokines, inflammation, menopause, resistance exercise