K. Avina-Padilla,M Duarte Gutierrez,M E Miranda Flores,J. C. Rivas-Ferreira,D Rivera Marquez,Nayra Avina Padilla,M O Guerrero Valle,
Erythroderma as a Paraneoplastic Cutaneous Disorder in Mantle Cell Lymphoma: A Case Report and Literature Review of Molecular Insights into Physiopathology
International Journal of Cancer Science and Therapy
2022

http://dx.doi.org/10.31487/j.IJCST.2022.02.01
https://www.sciencerepository.org/erythroderma-as-a-paraneoplastic_IJCST-2022-2-101 
Abstract: Mantle Cell Lymphoma (MCL) is a lymphohematopoietic cancer of follicular origin and diffuse growth. It is a rare small B-cell lymphoma, with an incidence of 7-10% of all non-Hodgkin lymphomas, affecting adults (55-60 years), of which 80% are typically male. According to the World Health Organization guidelines, the diagnosis of MCL should be established based on morphological examination and immunophenotyping with detection of cyclin D1 resulting from the chromosomal translocation t(11;14)(q13;q32) of the CCND1 gene or SOX11 protein overexpression. Herein we present an infrequent clinical case of a female patient with MCL who presented erythroderma as a paraneoplastic cutaneous disorder. Moreover, we delved into the molecular insights of immune B-cell lymphocytic affections in this communication.Keywords: Non-Hodgkin lymphoma, mantle cell, Ritter transformation, skin neoplasms