Samir Abbad  Andaloussi,Davy Louis  Versace,Estelle  Renard,Etienne  Dessauw,Valerie  Langlois,
Electrospun Nanofibrous Poly(3-Hydroxybutyrate-Co-3-Hydroxyvalerate) With Antibacterial Activity
Journal of Biology Engineering and Medicine
2019

http://dx.doi.org/10.31487/j.JBEM.2019.01.02
https://www.sciencerepository.org/electrospun-nanofibrous-poly-3-hydroxybutyrate-co-3-hydroxyvalerate-with-antibacterial-activity_JBEM-2019-1-102 
Abstract: Elaboration of electrospun nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBHV)-based
mats was implemented through two routes to obtain antibacterial material containing carvacrol, a phenolic
compound extracted from essential oils. The first strategy relied on a direct blend of PHBHV and
carvacrol/-cyclodextrin inclusion complexes, PHBHV (carvCD-IC), while the second approach implied
the elaboration of multilayered scaffold via the introduction of poly(β-CD-epichlorohydrin), PolyCD. The
PolyCD/carv-based mat was electrospun between two hydrophobic PHBHV mats. Scanning Electron
Microscopy analysis of mats showed uniform and beadless fibers. The three layered materials [PHBHV-
(PolyCD/carv)-PHBHV] is sufficient to ensure optimal antiradical activity (RSA of 88.6%) and exhibit
interesting antibacterial activities against E. coli and S. aureus.Keywords: poly (hydroxyalkanoate), PHBHV, electrospinning, antibacterial activity, antiradical property