Reham Z. Hamza,Fawziah A. Al-Salmi,Nahla S El-Shenawy,
Cardioprotective Effect of Zinc Oxide Nanoparticles/Green Tea Extract Complex on Monosodium Glutamate Toxicity
Journal of Biology Engineering and Medicine
2019

http://dx.doi.org/10.31487/j.JBEM.2019.01.03
https://www.sciencerepository.org/cardioprotective-effect-of-zinc-oxide-nanoparticlesgreen-tea-extract-complex-on-monosodium-glutamate-toxicity_JBEM-2019-1-103 
Abstract: Monosodium glutamate (MSG) is used worldwide as a food additive, the survey has disclosed some of
MSG's deleterious effects on various organs and tissues of rats. This research was achieved to determine the
impact of MSG on the albino rats' antioxidant and histology of cardiac tissue. 48 male rats were divided into
six groups of eight rats each. Group one used for monitoring and normal saline, whereas rats of group two
were given the lower dosage of MSG 6 mg/Kg, rats in group three received 17.5 m/kg body weight of
MSG, while rats in group four were given 10 mg/kg body weight of zinc oxide nanoparticles /green tea
extract (ZnO NPs/GTE) complex, the fifth and sixth groups were treated with the lower and the higher doses
of MSG with ZnO NP/GTE complex for 30 days. Each animal was sacrificed at the end of the treatment
period and the heart was thoroughly separated, determining the antioxidant parameter and the
histopathological changes. MSG administration to the rats has shown a substantial rise in peroxidation of
cardiac heart tissue, decline in the activities of catalase, superoxide dismutase, and glutathione peroxidase
beside the decrease in the glutathione level as compared to those in the control animals. The treatment the
induced-rats with MSG using complex showed some degree of recovery by a reduction in LPO of the heart
and enhancement of antioxidant enzymes. The findings suggested that the intrinsic antioxidant of the heart
tissue can significantly be alternated with the use of MSG in a dose-dependent manner and these changes
could be improved by using the green ZnO NPs complex. This complex acts as a factor to decrease the
histological damage that could be happening by the induction of MSGKeywords: ZnO NPs / Green tea complex, heart, antioxidants, histology