Mariam Anka,Therese Saad,Christelle Tayeh,Lama Charafeddine,
Use of Topical Nitroglycerine in the Neonatal Population Following Peripheral Tissue Ischaemia: Case Report and Updates about Safety Concerns
Journal of Clinical and Medical Case Reports
2021
2733-2268
http://dx.doi.org/10.31487/j.JCMCR.2021.02.02
https://www.sciencerepository.org/use-of-topical-nitroglycerine_JCMCR-2021-2-102 
Abstract: Neonatal thrombosis is a well-described morbidity occurring in the neonatal intensive care unit. Critically ill neonates are most vulnerable to developing thrombosis with serious complications. Fingers and toes ischaemia secondary to vascular occlusion following central lines insertion remains an uncommon occurrence. The therapeutic approach for peripheral tissue injury using local warming, anticoagulants, thrombolytics or topical hyaluronidase showed limited benefits and potential side effects. Here we report an unusual case of finger ischaemia treated successfully using topical nitroglycerine. This complements previous reports confirming the efficacy and safety of this drug and highlighting its potential benefit in neonates.Keywords: Neonatal thrombosis, nitroglycerine, limb ischaemia