Willy J. Malaisse,Zoheir Mellouk,
Deficient Activity of FAD-Linked Glycerophosphate Dehydrogenase in the Mitochondria of Insulin-Producing Pancreatic Islets B-Cells: A Possible Cause of the Metabolic Syndrome
Journal of Diabetes Metabolism and its Complications
2019
2674-4163
http://dx.doi.org/10.31487/j.JDMC.2019.02.03
https://www.sciencerepository.org/deficient-activity-of-fad-linked-glycerophosphate-dehydrogenase_JDMC-2019-2-103 
Abstract: A deficient activity of mitochondrial FAD-linked glycerophosphate dehydrogenase in insulin-producing
pancreatic islet B-cells was recently identified in selected animal models of non-insulin-dependent
diabetes mellitus. The incidence of this enzymatic defect remains however to be unambiguously
documented in type-2 diabetic patients. The present review mainly aims at speculating that the altered
recognition of nutrients, especially D-glucose, by pancreatic B-cells, as resulting from the abovementioned enzymatic perturbation could also eventually lead to the development of the metabolic
syndrome (MetS). Keywords: Metabolic syndrome, FAD-linked glycerophosphate dehydrogenase, pancreatic islet B-cells