David O.  Carpenter,Rija  Zehra,Syed S.  Fatmi,
Dietary Magnesium Intake and Heart Health
Journal of Food Nutrition and Metabolism
2018
2674-2411
http://dx.doi.org/10.31487/j.JFNM.2018.01.001
https://www.sciencerepository.org/dietary-magnesium-intake-and-heart-health_JFNM-1-101 
Abstract: With magnesium being the second most common intracellular cation in the human body and the presence
of hypomagnesemia in 10% of hospital admissions, magnesium deficiency has become a clinically
significant nutritional deficiency in context of heart health. Magnesium has long been used as a treatment
modality for cardiac arrhythmias as serum magnesium concentration of 1.44 mEq/L to 1.8 mEq/L has been
found to have a statistically significant inverse association with cardiovascular disease events. Patients with
the highest intake of magnesium were found to have incidents of sudden cardiac death reduced by 77%
while hypomagnesemia is found to be associated with increased risk of congestive heart failure and cardiac
arrhythmias. It has also been demonstrated that high dietary intake of serum magnesium is associated with
decrease in systolic and diastolic blood pressure secondary to reduction in vascular tone and an increase in
vasodilatory substances, like Prostaglandin E. Association of cardiovascular diseases with hypomagnesemia
and the need for the fulfilment of RDA goals, authenticates the use of oral magnesium supplements, with
established safety profile and lack of potential for toxicity.
Keywords:  Magnesium, recommended daily allowance, dietary intake, cation, hypomagnesemia, cardiovascular disease, hypertension, arrhythmia, atrial fibrillation, ventricular arrhythmia, heart failure