Zheng Zheng,Shuo-Yan An,Xiao-Fei Liu,Zhe Dong,Hu Zhang,Zhi-Wei Han,Ming-Jian Wang,Jin-Gang Zheng, Procedure and Effectiveness of Extracorporeal Membrane Oxygenation in Percutaneous Coronary Intervention for High-risk Complex Coronary Disease Journal of Integrative Cardiology Open Access 2020 2674-2489 http://dx.doi.org/10.31487/j.JICOA.2020.05.01 https://www.sciencerepository.org/procedure-and-effectiveness-of-extracorporeal-membrane-oxygenation-in_JICOA-2020-5-101 Abstract: Objective: It has been demonstrated that performing percutaneous coronary intervention (PCI) in the absence of mechanical circulation support (MCS) for patients with complex high-risk coronary artery disease bears a high risk. Alternatively, to figure out the procedure effectiveness and the mid-term prognosis of PCI for complex high-risk coronary artery disease, we accomplished the whole process by the assistance of extracorporeal membrane oxygenation (ECMO). Methods: Between July 2016 and October 2017, 6 consecutive complex and high-risk coronary disease patients underwent routine ECMO-supported PCI. Results: The average age of the patients was 70.5±11.98, and half of them (50%) were male. The mean creatinine (Cr) was 188.67±151.68 µmol/L. The average scores for SYNTAX, SYNTAX II, and LVEF pre the procedure was 41.33±12.14, 47.87±9.45 / 31.55±8.82, and 44.40±12.58%, respectively. The mean supporting duration of ECMO was 10.50±7.79 h. Regarding the postoperative complication, one case observed lower limp venous thrombosis and another reported infection at the access site. Two patients (33.3%) died for refractory heart failure during the follow-up course of 17.00±9.51 months, and the average net improvement index (NII) was 28.30±25.11% for this period. Conclusion: With the support of ECMO, the prognosis of complex high-risk coronary disease has shown to be improved by intervention in our study.Keywords: Percutaneous coronary intervention, mechanical circulation support, extracorporeal membrane oxygenation, prognosis