Di Wu,Haofan  Jin,Qiliang  Yin,Shijie  Lan,Yan  Wang,Yanping  Zhong,
Sarcomatoid Carcinoma of the Urinary Bladder: A Case Report
Journal of Surgical Oncology
2020
2674-3000
http://dx.doi.org/10.31487/j.JSO.2020.02.05
https://www.sciencerepository.org/sarcomatoid-carcinoma_JSO-2020-2-105 
Abstract: Introduction: Sarcomatoid carcinoma describes a biphasic malignancy with features of epithelial and
mesenchymal differentiation. It rarely occurs at the urinary bladder but is usually aggressive and associated
with poor prognosis.
Case Presentation: We here report a case of sarcomatoid carcinoma of the urinary bladder of a 48 years
old man with intermittent painless haematuria over an 18-month period. Imaging examination showed
intraluminal protrusion of a tumour on the right posterior wall of the bladder.
Diagnosis: The patient was initially diagnosed as a right bladder mass.
Interventions: The patient underwent two rounds of transurethral resection of bladder tumour (TURBT)
and pathological analysis suggested the tumours were invasive urothelial carcinomas. Radical cystectomy
was later performed, and pathological analysis suggested a stage T4 sarcomatoid carcinoma. The patient
received 5 cycles of gemcitabine and cisplatin.
Outcome: The patient died of multiple organ dysfunction syndrome 8.5 months after the diagnosis of
sarcomatoid carcinoma.
Conclusion: Sarcomatoid carcinoma of the urinary bladder is a highly malignant disease, and the
histopathological characteristics are distinct. The diagnosis, surgical management, and chemotherapy of this
patient are discussed together with previous cases reported in the literatureKeywords: Sarcomatoid carcinoma, bladder carcinoma, immunohistochemistry, radical cystectomy, chemotherapy