Quanxin Su,Shenglin  Gao,Jiasheng  Chen,Lifeng Zhang,Li Zuo,
Prophylactic Urethrectomy Could Further Shorten the Female Bladder Cancer Recurrence and Metastasis
Journal of Surgical Oncology
2020
2674-3000
http://dx.doi.org/10.31487/j.JSO.2020.04.07
https://www.sciencerepository.org/prophylactic-urethrectomy-could-further-shorten-the-female-bladder-cancer-recurrence_JSO-2020-4-107 
Abstract: Objective: To compare the clinical effects and safety of two methods of laparoscopic total cystectomy for
female bladder cancer patients with retention and resection of the urethra.
Methods: Female bladder cancer patients with bladder invasive urothelial carcinoma were selected in grade
II~III from January 2008 to March 2018. Patients were divided into two groups based on the surgical
method: group A laparoscopic radical cystectomy, and group B laparoscopic radical cystectomy +
urethrectomy, to observe the clinical efficacy, operation duration, blood loss during surgery, hospitalization
time, and complications.
Results: The operation times in groups A and B were 262.54 ± 27.95 min and 310.28 ± 32.99 min,
respectively. The volumes of intraoperative blood loss in groups A and B were 439.46 ± 44.52 mL and
456.74 ± 47.18 mL, respectively. There were no discernable differences in the probability of postoperative
complications in the two groups. In group A, four patients experienced bladder cancer recurrence and
metastasis, and 50% of these cases had a urethral recurrence. In group B, one patient experienced bladder
cancer recurrence and metastasis; however, there was no urethral recurrence.
Conclusion: Although laparoscopic radical cystectomy + urethrectomy extended the operation times;
prophylactic urethrectomy can further shorten the bladder cancer recurrence and metastasis and improve
patient prognosis without an increase in complications. However, its long-term clinical efficacy needs
further study and supplement.Keywords: Bladder cancer, female, laparoscopic radical cystectomy, urethrectomy