Bryan Kolb,Preston  Williams,
A Review of Pre-Clinical Studies for the Treatment of Neonatal Brain Injury
Neurology and Neurobiology
2020
2613-7828
http://dx.doi.org/10.31487/j.NNB.2020.01.07
https://www.sciencerepository.org/a-review-of-pre-clinical-studies_NNB-2020-1-107 
Abstract: The developing brain is especially sensitive to perturbations such as hypoxia-ischemia (HI) or surgical
ablation in the perinatal period. We first review and contrast the effects perinatal HI and surgical
perturbation in laboratory rats. The developing brain is also very responsive to a wide range of other
experiences that can induce remarkable neural plasticity in both the normal and perinatally injured brain.
We next review the factors that influence this plasticity in both the normal and perinatal injured. We consider
treatments that stimulate cerebral and behavioural plasticity, especially in the motor systems. The goal is to
draw attention to possible treatments that could be translated from perinatal surgical ablation to the HI model
and eventually to the clinic.
Keywords: Perinatal injury, post-injury therapy, neural plasticity, FGF-2