Alberico Marielisa,Bellizzi Annamaria,Benigni Giovanni,Botticella Filomena,C.A. Tammaro,Capaldo Guglielmo,Corbo Antonio,Corbo Giulia,De Caro Monica,Dragonetti Carmela,Ferrara Maurizio,Fiori Patrizia,Gennaro Bellizzi,Gizzi Raffaele,Guerriero Barbara,Iorillo Luigi,L.M. Giannetti,Manganelli Gianvito,Massarelli Marco,Mazza Emerico,Minichiello Stefania,Monaco Antonio,Morella Alessandro,Pace Erminio,Pellecchia Vincenzo,Pelosi Chiara,Savino Patrizia, Central Genesis of Dysrhythmia Neurology and Neurobiology 2020 2613-7828 http://dx.doi.org/10.31487/j.NNB.2020.02.02 https://www.sciencerepository.org/central-genesis-of-dysrhythmia_NNB-2020-2-102 Abstract: Introduction: The central nervous system is the generator of the dynamic balance between cholinergic and noradrenergic activity. Different behavioral tendencies are observed in subjects with prevalent parasympatic tone (defense strategy, energy sparing, dissociation) compared to those with sympathic one (relational interaction, high energy expenditure). These responses may influence susceptibility and vulnerability to diseases. The aim of our study was to examine cardiovascular function from the heart to the periphery by 24 hours detection of both heart and pulse rate in cerebrovascular conditions. Materials and Methods: We recruited 113 Acute Ischaemic Syndromes (AIS, age 73,43 sd 12,34), 32 Chronic Cerebro-Vascular Diseases (CCVD, age 75,95 sd 8,06), 30 Other Neurological Diseases (OND, age 50,09 sd 15,05). Cardiovascular reactivity (CR) was defined by beat indices, ratio (R) or difference (D) between higher maximal or minimal heart rate (HR) on higher maximal or minimal pulse rate (PR). A value < 1 or > 1 were considered as negative (NCR) or positive CR (PCR), respectively. Results: Max PR was significantly higher in CCVD and AIS compared to OND. Max CR was lower in CCVD and AIS compared to OND. Increased levels of glycosylated hemoglobin, cardiac biomarkers, abnormal findings at Holter ECG and Echocardiography were particularly observed in case of NCR. Conclusions: NCR may interfere with normal activity of daily living. Higher Hachinski ischaemic scores in these patients point out a higher ischaemic load. Moreover, NCR identified a category of acute patients with worst outcomes, requiring prompt intensive care because of higher risk of complications and mortality. Our observations may be useful for better choosing among therapeutical options, planning rehabilitation and health enhancing physical activity in aging. Moreover, they may reduce the risk of injuries for training overload in athletes.Keywords: Acute ischaemic syndromes, chronic cerebro-vascular diseases, cardiovascular reactivity, cardiac biomarkers, glycosylated haemoglobin, inflammatory parameters