Manuel Encarnacion Ramirez,Rossi Evelyn Barrientos Castillo,Gerald Musa,Renat Nurmukhametov,Boris O. Igorevich, ‘Brain Tissue Out’ in a Train Struck Victim: A Case Report Neurology and Neurobiology 2022 2613-7828 http://dx.doi.org/10.31487/j.NNB.2022.02.02 https://www.sciencerepository.org/brain-tissue-out-in_NNB-2022-2-102 Abstract: Background: ‘Brain tissue out’ (BTO) is used here to describe traumatic acute extracranial cerebral herniation, an extreme manifestation of severe TBIs. Case Description: We report a case of a 15-year-old victim of a severe head injury who was brought with acute extracranial cerebral herniation ‘brain tissue out’. We review the current literature and evidence of this exceedingly rare presentation. Conclusion: 'Brain tissue out' is a rare form of severe head injury with a very poor prognosis. The possible catastrophic short long-term effects of this injury warrant further attention to clarify the underlying mechanisms and to identify its management guidelines.Keywords: Severe head trauma, brain tissue herniation