Cassandra A Ligh ,Katie Magoon,Paris D. Butler, Keloids of the Lower Abdomen, Mons and Vulva: Several Case Studies Highlighting a Successful Approach to Treatment Radiotherapy and Clinical Oncology 2020 2674-2497 http://dx.doi.org/10.31487/j.RCO.2020.01.01 https://www.sciencerepository.org/keloids-of-the-lower-abdomen_RCO-2020-1-101 Abstract: Background: Perineal keloids can have an overwhelming impact on patients’ lives including pain, skin breakdown, infection, and interference with intercourse. There is a paucity of literature addressing the effective treatment techniques. Cases: Three case of perineal keloid treatment, with at least 13-month follow up, are presented. All patients are African American females who were recommended a treatment plan that combined surgical wide local excision and radiation therapy. All patients had aesthetically acceptable outcomes with recurrence-free results at least 13-months post procedure. Conclusions: These three cases describe the successful treatment of perineal keloids that utilize a combination of surgical excision with targeted radiotherapy. This approach can be offered to patients with recurrent keloidal masses and the presented principles can be utilized to achieve recurrence-free results. Teaching Points: 1. Readers will understand the basics of the pathophysiology of keloid formation and their effect on patients who experience them in sensitive areas such as the mons, vulva, and/or lower abdomen. 2. Readers will be able to describe and implement the described technique for management of keloids in these potentially sensitive areas.Keywords: Keloids, lower abdomen keloids, mons keloids, keloid treatment technique, hypertrophic scar, scar, collagen