Hui Peng,Jianzhong  ZHU,Jing Wang,Lei Yu,Lin Han,Mingxue Fan,Yiting  Wang,Zhiqiang Yan,
A novel theranostics nanoparticles pGGA-PTX / SPION with bifunction of diagnosis and treatment
Radiology and Medical Diagnostic Imaging
2018
2613-7836
http://dx.doi.org/10.31487/j.RDI.2018.10.06
https://www.sciencerepository.org/a-novel-theranostics-nanoparticles-pGGA-PTX-SPION-with-bifunction-of-diagnosis-and-treatment_RDI-1-106 
Abstract: To increase the solubility of free drugs, drug-loaded efficiency and prolong the half-life of drugs in the
body, a novel theranostics nano-particles, pGGA-PTX / SPION with a good diagnosis and treatment
function have been fabricated. It is plump and uniform in size, to 113.0 ± 0.6nm, leading to the passive
targeting of tumor tissue due to the EPR effect. The content-loaded of PTX was about 27.66%. The contrast
agent content was about 6.34%. In vitro evaluation such as cell viability, the pGGA-PTX / SPION NPs were
similar to that of PTX, suggesting a useful anticancer effect on tumor cells. In the H&E experiment, the
pGGA-PTX / SPION did not impair the normal tissue and fully proved its safety performance. In vivo
imaging, the pGGA-PTX / SPION in the tumor body can clearly be observed by NMR, to achieve real-time
monitoring of drugs. In vivo treatment effects experiment, the pGGA-PTX / SPION exhibits a significant
tumor growth inhibition effect.Keywords: Polymer delivery system, diagnosis and treatment, nanoparticles, contrast agent, PTX (Paclitaxel)