Francesco Saverio Ludovichetti,Maurizio Ludovichetti, A 6 years follow-up comparison of two dental implants: bioactive vs DAE surface, a clinical case report International Journal of Regenerative Medicine 2018 2613-5914 http://dx.doi.org/10.31487/j.RGM.2018.10.005 https://www.sciencerepository.org/a-6-years-follow-up-comparison-of-two-dental-implants-bioactive-vs-DAE-surface-a-clinical-case-report_RGM-1-105 Abstract: Introduction: The aim of the present study is to describe a case report of lower molars substitution with 2 different dental implants. One with a DAE surface and one with a type 1 collagen coated surface. Case presentation: In the present study, a 54-year-old man presented the absence of the first and second molars both on the left and on the right mandible. After clinical and radiographic evaluation, implant therapy was chosen to substitute the missing teeth. On the right mandible, a DAE surface implant was placed while on the left mandible, a bovine Type 1 collagen of dermal origin (custom made medical device) surface implant was placed. A radiographic 6 years follow up was performed. Discussion: The Type 1 collagen coated surface dental implant did not show any marginal bone loss after 6 years, moreover, it showed a bone gain after 3 months from its placement and kept it for 6 years while the traditional surface implant showed an immediate marginal bone loss. Keywords: Dental implants, type 1 Collagen, bioactive surface