Dries  Deeren,
Cure of cerebral lymphoma with only one course of chemotherapy: was dr. House right after all?
International Journal of Regenerative Medicine
2019
2613-5914
http://dx.doi.org/10.31487/j.RGM.2019.02.01
https://www.sciencerepository.org/cure-of-cerebral-lymphoma-with-only-one-course-of-chemotherapy-was-dr-house-right-after-all_RGM-2019-2-101 
Abstract: We report on an elderly patient with primary diffuse large B-cell lymphoma of the central nervous system.
Despite dose reduction of methotrexate (MTX), he developed acute renal failure with creatinine increase to
3.3 mg/dl and stomatitis grade 3. CT scan 16 days after chemotherapy showed complete remission. Because
of the very poor tolerance of therapy and the complete response we decided to follow-up carefully but not
put him through further treatment after this single administration of MTX. Now, 7 years later, he is still in
complete remission and enjoys a great life quality, living with his family. Like a patient in a House episode,
he suffered from serious complications of chemo, but this one chemo course saved his life. Renal failure
may have caused longer circulation of MTX and extended antineoplastic activity as well as toxicity. This
challenges the classic view that therapy dose should be reduced in elderly patients. Outcome may be good
despite age or toxicity.
Core tip: We challenge the classic view that therapy dose should be reduced in elderly patients. Outcome
may be good despite age or toxicity.Keywords: Lymphoma, non-Hodgkin, brain neoplasms, cytostatic agents, aged, renal insufficiency