Sunil Wimalawansa,
Maintaining Optimum Health Requires Longer-Term Stable Vitamin D Concentrations
International Journal of Regenerative Medicine
2020
2613-5914
http://dx.doi.org/10.31487/j.RGM.2020.03.03
https://www.sciencerepository.org/maintaining-optimum-health-requires-longer-term-stable-vitamin_RGM-2020-3-103 
Abstract: Humans are constantly invaded by environmental microbes. The body is protected from pathogen attacks
by the immune defense system. In 99.8% of the time, our innate immune system is capable of getting rid of
these organisms without before these can cause harm. Those who are with weaker immune systems
constantly get infections and having chronic diseases. Among many factors contributing to maintaining a
robust immune system, vitamin D has the highest impact. It has a major protective effect against acute
respiratory infections and subduing both communicable and non-communicable diseases. A healthy person
with stronger immunity may not manifest clinical signs and symptoms of COVID-19-silent, asymptomatic
carriers of the virus and can be infectious. Whereas not all PCR positive persons are infectious. A rapid
response occurs through the innate system that is followed by the adaptive response that lasts a longer
period. Vitamin D kick starts both systems. However, the protective immune and other functions are damped
in the presence of hypovitaminosis and also when the levels are fluctuating. Thus, the importance of
maintaining serum 25(OH)D at a steady level above 30 ng/mL. When maintaining such, among all nutrients
vitamin D has the widest benefits to multiple body systems. Thus, this sunshine vitamin (a steroid hormone)
has been modulated through evolution to emerge as a key survival mechanism in humans. Nevertheless,
vitamin D is not a panacea.Keywords:  Coronavirus, infection, equatorial, innate immune system, vitamin D, PCR testing