Kevin  Nguyen,Jonathan  Gootee,Sarah  Aurit,Sara  Albagoush,Christina Curtin,Peter  Silberstein,
Risk Factors of Survival in Dedifferentiated Liposarcoma
Surgical Case Reports
2021
2613-5965
http://dx.doi.org/10.31487/j.SCR.2021.02.02
https://www.sciencerepository.org/risk-factors-of-survival-in-dedifferentiated-liposarcoma_SCR-2021-2-102 
Abstract: Background: Liposarcoma is the most common malignant soft tissue sarcoma for which surgical resection
is the most utilized therapeutic option. In this study, we aimed to explore the associations of surgical margins
among other risk factors on survival in patients with dedifferentiated liposarcoma.
Patients and Methods: The National Cancer Database (NCDB) was used to select patients with
dedifferentiated liposarcoma to determine if surgical margins were associated with worse overall survival
after controlling for age, gender, race, Charlson-Deyo score, anatomic site, treatment approach, tumor size,
tumor grade, and presence of metastases through multivariable analysis.
Results: Multivariable analyses showed that mortality risk increased for dedifferentiated liposarcoma
patients with the following: older age, male, metastasis, high tumor grade, macroscopic residual tumor
compared to no residual tumor.
Conclusion: Older age, male sex, presence of metastasis, retroperitoneal/abdomen primary site, high grade
tumors, and macroscopic residual tumor present after surgery led to an increased risk of mortality.Keywords:  Dedifferentiated liposarcoma, surgical margins, retroperitoneum, survivorship, National Cancer Database