Extra-Gonadal Teratomas in Atypical Sites in Neonates and Children – Our Experience and Review of the Literature

A B S T R A C T

Background: Extra-gonadal teratomas are rare tumors in Pediatric surgical practice. We studied the teratomas of atypical sites attended in our tertiary care center.
Aim: Aim of the study was to find out the incidence of pediatric teratomas in atypical sites, clinical presentation and histological variation.
Material and Methods: Over 15 years (January 2005 to December 2020), 29 cases of pediatric teratomas in atypical sites were studied. These sites included neck (number-one), retroperitoneum (number-fourteen), adrenal gland (number-two), renal (number-two), gastric(number-three), pancreas (number-one), pulmonary (number-one), floor of the mouth(number-one), oral (number-two), abdominal wall (number-one) and the mesentery (number-one). Patients were treated in the Department of Pediatric Surgery and specimens were reviewed in the Department of Pathology. Age, sex, clinical presentation, investigations (all patients had complete blood examination and alpha-fetoprotein) and imaging (USG of the local part and CECT as guided by the organ of involvement).
Results: 29 pediatric teratomas in uncommon sites were reviewed. Out of 14 cases of retroperitoneal teratoma, three were immature. Cervical teratoma in a neonate was mature. Three cases of gastric teratomas were reported as mature. Two cases of adrenal teratomas also showed the histological features of mature teratoma. Renal teratomas (two) were benign. One each of pulmonary teratoma, pancreas and floor of the mouth were reported as mature. Two patients presented with oral teratoma were reported as mature teratomas. One patient had teratoma arising from the abdominal wall and was resected completely (mature teratoma). Teratoma arising from the mesentery also underwent complete resection.
Conclusion: A small percentage of Pediatric teratomas occur in atypical sites. In our series, retroperitoneal tumors were predominant. Early surgical excision is the treatment of choice. Malignant change is known to occur in Pediatric teratoma and the patients need long term follow-up.

Keywords

Pediatric, retroperitoneum, neonates, teratoma, atypical sites, gastric, adrenal, pancreatic, the floor of the mouth, pulmonary, teratoid Wilms’, alpha-fetoprotein (AFP)

Introduction

The teratomas in gonads and sacrococcygeal area are relatively common neoplasms seen in pediatric surgical practice [1, 2]. Teratomas in extra-gonadal sites are uncommon, varied in presentation and unpredictable biological behaviour [3]. The teratomas are embryonal tumors derived from at least 2 of 3 germ cell layers which differentiate into identifiable tissues and organs in ectopic locations [3]. Mature teratomas are known to undergo malignant change and they need long term follow-up [4]. The rare sites where teratomas are located are retroperitoneal space, mediastinum, pulmonary, stomach, the floor of mouth, tongue, kidney, thyroid, liver, heart, lung, fallopian tube, placenta [4]. We share our experience of teratomas arising in the retroperitoneum, neck, kidney, stomach, adrenal, pulmonary, the floor of the mouth, the pancreas, oral cavity, abdominal wall and the mesentery.

Material and Methods

The authors of the present study reviewed their experience on teratomas in extra-gonadal sites (retroperitoneum, neck, adrenal, renal, pulmonary, floor of the mouth, pancreas, oral cavity, abdominal wall, mesentery). Tables 1 & 2 show the age, sex, site, treatment, nature of the tumor and follow-up in the retroperitoneal area and other uncommon sites respectively. In 14 cases of retroperitoneal teratomas, 11 were reported as mature and 3 were immature as shown in (Table 1). All of them had baseline investigations (CBC, urine microscopic examination, renal functions). Alpha-fetoprotein (AFP) was done in all cases and was raised in immature teratomas. After the surgical procedure, the specimens were sent to the Department Pathology. The study was carried out over a period 15 years from January 2005 to December 2010. 106 cases of pediatric teratoma were analysed in the Department of Pathology. Out of these, 29 cases were teratoma at atypical sites.

Table 1: Retroperitoneal teratomas.

Age	Sex	Site	Treatment	Histology	Follow-up
6 d	M	Mid-abdomen	CE	Immature	Lost after 6M
7 y	M	Whole abdomen	CE	Mature	Well after 10 y
3 y	F	Right lower abdomen	CE	Mature	Well after 5 y
1 y	F	Mid abdomen	CE	Mature	Well after 10 y
9 y	M	Mid abdomen	CE	Mature	Well after 10 y
7 m	F	Lower abdomen	CE	Immature	Well after 1 y
18 m	F	Right lower abdomen	CE	Mature	Well after 11 y
30 m	F	Mid abdomen	CE	Mature	Well after 12 y
3 y	F	Left lower abdomen	CE	Mature	Well after 10 y
7 y	M	Mid abdomen	CE	Mature	Well after 10 y
2 m	F	Lower abdomen	CE	Immature	Died after 1 y
11 y	F	Mid abdomen	CE	Mature	Well after 4 y
6 m	M	Right lower abdomen	CE	Mature	Well after 7 y
12 m	F	Mid abdomen	CE	Mature	Well after 12 y

d: days; y: year, M-Male; F-Female; CE: Complete Table 2: Teratomas in other uncommon sites.

Age	Sex	Site	Treatment	Histology	Follow-up
18 m	M	Stomach	CE	Mature	Well 5y
3 m	F	Stomach	CE	Mature	Well 4y
24 m	M	Stomach	CE	Immature	Died after 3m
2 m	F	Kidney	CE	Mature	Well after 10 y
7 m	F	Kidney	CE	Mature	Well after 11 y
7 y 5 m	F	Adrenal	CE	Mature	Well after 6 y
1 y	M	Adrenal	CE	Mature	Well after 5y
4 y	M	Lung	CE	Mature	Lost to FU 2y
10 m	F	Pancreas tail	CE	Mature	Well after 8y
2 d	M	Neck	CE	Mature	Well after 10 y
1 d	F	Oral	CE	Mature	Well after 1 y
12 d	M	Oral	CE	Mature	Lost to FU 3m
4 m	F	Floor mouth	CE	Mature	Well after 11 y
1 y	M	Abdominal wall	CE	Mature	Well after 6 m
3 m	M	Mesentery	CE	Mature	Well after 3y

d: days; y: year, M-Male; F-Female; CE: Complete Excision

Results and Analysis

Among 106 cases of pediatric teratomas, 29 cases were teratoma of atypical site. 14 were retroperitoneal teratoma, 3 cases were gastric teratoma, 2 cases were adrenal teratoma, 1 cervical teratoma, 1 pulmonary teratoma, 2 in the kidney, 1 occurred in the floor of the mouth, one in the pancreas, two from the oral cavity, one from the abdominal wall. The commonest rare site was retroperitoneum.

I Retroperitoneal Teratoma

Out of 14 cases 9 were female and 5 were male. The youngest patient was 2-day-old male and the oldest patient was 7-year-old male. Most of the patients of retroperitoneal teratoma presented with gradually increasing swelling of the abdomen. The 2-day-old patient presented with absence of passing urine since birth. A 4-day-old male was diagnosed as a mesenteric cyst on ultrasound. 4-year-old female presented with left iliac mass. The specimens were partly cystic and partly solid in nature nodule or irregular in shape and maximum dimension was 15 cm. On cut section, most of them had a visible bone, cartilage, hair, sebaceous material and greyish white neural tissue. Some had intestinal epithelium, bronchial epithelium, thyroid tissue and small glandular spaces lined by columnar epithelium. The specimen of 4-day-old female was mostly solid. The maximum diameter of the removed tumor was 10.5 cm. On histopathological examination, immature neuroepithelial tissue and immature cartilage were found. It was an immature teratoma. Rest 11 cases were mature teratoma.

A 2-month-old male and another 1-month-old male came with epigastric swelling. All these patients had imaging (X-ray abdomen, ultrasonography and CECT abdomen) (Figure 1). Complete surgical resection the mass was done in all the cases (Figure 2) is showing an operative picture of one of our retroperitoneal teratomas. The histopathological examination revealed mature cartilage, neuroepithelial tissue and fatty tissue. In two patients of immature teratoma, follow-up AFP was within normal limit and no adjuvant therapy was given. One patient was lost to follow-up 6 months after surgery. One patient was doing well one year after surgery. Only one patient of immature retroperitoneal teratoma, operated at the age of 2 months, was recommended adjuvant chemotherapy but the parents refused chemotherapy. This baby died one year after surgical excision.

II Gastric Teratoma

We treated three patients aged 18 months (male), 3 months (female) and 24 months (male). They presented with abdominal distension and vomiting. One patient had melena. An epigastric lump was palpable in all the cases. The patient with melena had severe anaemia. All patients required pre-operative stabilisation, baseline investigations, USG abdomen, gastroduodenoscopy, CECT abdomen. In two patients the mass was in the posterior wall and the other patient had a mass along the greater curvature. Complete excision of the mass was done along with partial gastrectomy. Postoperative recovery was uneventful. Two patients had mature teratoma and were doing well after 5 and 6 years respectively. Patient aged 3 months with immature teratoma was advised to come after 2 weeks of discharge but did not turn up for follow-up.

III Cervical Teratoma

2- day-old baby presented with cervical swelling (Figure 3). Clinically it was a solid mass but at the base, some lesions were looking like cystic hygroma. The mass was bleeding from the surface of the tumor. Baseline investigations, AFP, ultrasonography of neck was done. The patient was stabilised and the swelling was excised as it was bleeding. The specimen was solid and hemorrhagic. The histopathological diagnosis was mature teratoma. This patient was last seen 10 years after operation and was well.

IV Pulmonary Teratoma

A 4-year-old boy came with respiratory distress with left side chest pain. CECT showed a mass in the left lung (Figure 4). The mass was excised completely and histopathology showed that the evidence of mature teratoma. This patient was well 2 years after surgery but lost to follow-up.

V Adrenal Teratoma

One 7-year and 5-month-old female came with pain in the right hypochondriac and another one year male came with pain in the left hypochondrium. USG abdomen and CECT abdomen confirmed the diagnosis (Figure 5) of right adrenal teratoma. In both cases, the mass was found in the right and left adrenal respectively and was excised completely. Right adrenal teratoma was bigger as shown in the operative picture (Figure 6). They were partly cystic and partly solid and diagnosed as mature teratoma. The patients were followed up for 6 years and 5 years respectively and were doing well.

VI The Floor of the Mouth

A 4-month-old female came with a midline swelling in the floor of the mouth (Figure 7). It was a swelling measuring 3 cm in diameter. Complete excision of the mass revealed intestinal glands (Figure 8) and mature cartilage on histopathology examination. The patient was last seen 11 years after surgery and was doing well.

VII Pancreas Tail

A 4-year- old male patient presented with a lump in the upper abdomen. USG and CECT abdomen revealed a mass arising from the pancreas (Figure 9). The tumor was arising from the tail of the pancreas and was completely removed (Figure 10). Histopathology was reported as mature teratoma. Doing well 8 years after the operation.

VIII Renal Teratoma

We encountered two cases of renal teratoma. They presented with an abdominal lump. Baseline investigations, X-Ray abdomen, USG abdomen and CECT abdomen were done. Because of the presence of calcification in the imaging AFP was done and was within normal limit. Nephrectomy was done and was reported as mature teratoma. Patients were doing well 10 and 11 years respectively after the operation.

IX Abdominal Wall

One year boy presented to us with the lump on the abdominal wall (Figure 11). Initially, the parents were not willing for surgical excision as the parents were from the poor socio-economic condition and were earning money by showing the baby. Later on, they were convinced that this tumor may cause a problem in day to day activities of the baby and agreed for surgery. Complete surgical excision was done and the tumor was mature. The patient was lost to follow-up after 6 months of surgery.

X Oral Teratoma

We treated two babies (one day and 12 days) of oral teratoma (Figure 12 of one day baby). The tumors were completely excised and were mature in nature. One patient was doing well 1 year after surgery but the other patient was lost to follow-up.

XI The Mesentery

One infant aged 3 months presented with abdominal distension and vomiting. There was a lump in the mid-abdomen. Imaging showed features of small bowel obstruction. Laparotomy revealed a mass arising from the mesentery and was completely excised. Histopathology report was mature teratoma. The patient was doing well 3 years after surgery.

Discussion

Teratoma is defined as a tumor that is composed of tissues derived from more than one primitive germ cell layer and at least some of the tissues are foreign to the site in which it occurs. Retroperitoneal teratomas are the third most common tumors next to neuroblastoma and Wilms’ tumor in Pediatric age group [5]. Most of the retroperitoneal teratomas present with an abdominal lump [6]. USG abdomen, CECT abdomen is usually diagnostic. Aspiration cytology has been reported in some studies [7]. Alpha-fetoprotein (AFP) (preoperative and during postoperative follow-up) is done in all cases. Complete excision was possible in our cases. Three patients had immature teratoma but were followed up as the follow-up AFP was normal. Surgical excision is possible even in bilateral involvement and serum AFP is a reliable method of follow-up to detect recurrence [8]. Association of Down’s syndrome and retroperitoneal teratoma has been reported but we did not see any patient with Down’s syndrome in our series [9]. Gastric teratoma constitutes less than 1% of all germ cell tumors in the pediatric age group [10]. Most of the patients present with an abdominal lump, abdominal distension, vomiting, haematemesis or melena [11]. Complete surgical excision along with partial gastrectomy/ gastrectomy is curative in most of the cases [12]. Gastric teratoma including immature variety has an excellent prognosis after complete surgical excision. Adjuvant chemotherapy is recommended if there is rising AFP, and grade III immature teratoma. However, the role of chemotherapy in immature teratoma is not very clear because of limited experience and uncertain biological behaviour of these neoplasms [13].

Cervical teratomas are rare in neonates [14]. EXIT procedure (ex utero intrapartum treatment) has been described in cervical teratoma with fetal distress [14]. Neonatal cervical teratoma sometimes misdiagnosed as cystic hygroma as in one of our cases [15]. Complete excision is curative in most of the cases. Long term clinical follow up and happened biological tumor marker is mandatory to detect recurrence. Antenatal diagnosis has also been reported [16]. Pulmonary teratoma was first described by Mohr in 1939. Isolated case reports are available in the English literature [17]. It is believed that intrapulmonary teratomas are derived from the third endodermal pharyngeal pouch [17]. Respiratory distress and recurrent pulmonary infection are the usual modes of presentations. CECT chest (Figure 4) was confirmatory in our case. Complete excision of the tumor was possible in our patient. Histopathology was reported as mature. Pre-operative and post-operative AFP was normal.

Adrenal teratoma in Pediatric age group is extremely rare [18]. Adrenal teratoma may present with a lump or with the acute abdomen [2]. USG abdomen and CECT abdomen confirm the diagnosis. Complete surgical excision is most of the time curative. Both the cases in our series were followed up for more than 10 years and are doing well. Adrenocortical carcinoma should be considered as differential diagnosis and in suspected cases, hormonal assessment should be done. Teratoma arising from the pancreas is also extremely rare and was first described by Kerr [19-21]. Pancreatic teratomas usually present with an abdominal lump. MRI / CECT usually delineate the site and nature of the tumor. Except for AFP, other tumor markers like enolase, carcinoembryonic antigen, lack specificity and sensitivity. In our patient, the tumor was involving the tail of the pancreas and complete resection was possible. There was no exocrine and endocrine dysfunction during follow-up.

The incidence of renal teratoma is rare [22]. We reported a patient of renal teratoma with duplication of cecum and appendix in 2010 [23]. Mature teratomas must be differentiated from teratoid Wilms’ tumor [23]. There are reports where patients with pure immature teratomas are treated by surgical excision alone with 85% event-free interval for more than 3 years [22]. Oropharyngeal teratoma constitutes only 2% of all pediatric teratomas [24]. Reported incidence in oral cavity is 1:20,000 to 1: 40,000 [25]. Epignathus are teratomas which contain fully developed organs and appendages. One of our oral teratomas fulfilled the criteria of epignathus (Figure 12). Early complete surgical excision is the treatment of choice. Mesenteric teratoma is extremely rare [26]. We encountered only one case in our series. Diagnosis is made after laparotomy in most of the cases. Complete surgical excision is curative in mature teratomas.

Abbreviations

USG: Ultrasonography
CECT: Contrast-Enhanced Computed Tomography
MRI: Magnetic Resonance Imaging
CBC: Complete Blood Count

Article Info

Article Type

Case Series and Review of the Literature

Publication history

Received: Thu 14, Jan 2021
Accepted: Thu 28, Jan 2021
Published: Fri 12, Feb 2021

Copyright

© 2023 Biswanath Mukhopadhyay . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.COR.2021.02.03

Author Info

Madhumita Mukhopadhyay Kartik Chandra Mandal Chhanda Das Brati Mukhopadhyay Biswanath Mukhopadhyay Pankaj Halder

Corresponding Author

Biswanath Mukhopadhyay
Department of Pediatric Surgery, Apollo Gleneagles Hospital, Kolkata, India

Figures & Tables

Table 1: Retroperitoneal teratomas.

Age	Sex	Site	Treatment	Histology	Follow-up
6 d	M	Mid-abdomen	CE	Immature	Lost after 6M
7 y	M	Whole abdomen	CE	Mature	Well after 10 y
3 y	F	Right lower abdomen	CE	Mature	Well after 5 y
1 y	F	Mid abdomen	CE	Mature	Well after 10 y
9 y	M	Mid abdomen	CE	Mature	Well after 10 y
7 m	F	Lower abdomen	CE	Immature	Well after 1 y
18 m	F	Right lower abdomen	CE	Mature	Well after 11 y
30 m	F	Mid abdomen	CE	Mature	Well after 12 y
3 y	F	Left lower abdomen	CE	Mature	Well after 10 y
7 y	M	Mid abdomen	CE	Mature	Well after 10 y
2 m	F	Lower abdomen	CE	Immature	Died after 1 y
11 y	F	Mid abdomen	CE	Mature	Well after 4 y
6 m	M	Right lower abdomen	CE	Mature	Well after 7 y
12 m	F	Mid abdomen	CE	Mature	Well after 12 y

d: days; y: year, M-Male; F-Female; CE: Complete Table 2: Teratomas in other uncommon sites.

Age	Sex	Site	Treatment	Histology	Follow-up
18 m	M	Stomach	CE	Mature	Well 5y
3 m	F	Stomach	CE	Mature	Well 4y
24 m	M	Stomach	CE	Immature	Died after 3m
2 m	F	Kidney	CE	Mature	Well after 10 y
7 m	F	Kidney	CE	Mature	Well after 11 y
7 y 5 m	F	Adrenal	CE	Mature	Well after 6 y
1 y	M	Adrenal	CE	Mature	Well after 5y
4 y	M	Lung	CE	Mature	Lost to FU 2y
10 m	F	Pancreas tail	CE	Mature	Well after 8y
2 d	M	Neck	CE	Mature	Well after 10 y
1 d	F	Oral	CE	Mature	Well after 1 y
12 d	M	Oral	CE	Mature	Lost to FU 3m
4 m	F	Floor mouth	CE	Mature	Well after 11 y
1 y	M	Abdominal wall	CE	Mature	Well after 6 m
3 m	M	Mesentery	CE	Mature	Well after 3y

d: days; y: year, M-Male; F-Female; CE: Complete Excision

Figure 1: CECT abdomen showing retroperitoneal teratoma.

Figure 2: Retroperitoneal teratoma presented with lump and intestinal obstruction.

Figure 3: Neonatal cervical teratoma initially diagnosed as cystic hygroma.

Figure 4: CECT lung showing pulmonary teratoma.

Figure 5: CECT abdomen showing right adrenal teratoma with mass and calcification.

Figure 6: Operative picture of right adrenal teratoma.

Figure 7: Teratoma arising from the floor of the mouth.

Figure 8: Mature teratoma showing intestinal glands (H & E 400X).

Figure 9: CECT abdomen showing tumor arising from the tail of the pancreas.

Figure 10: Operative picture of pancreatic teratoma arising from the tail.

Figure 11: Abdominal wall teratoma.

Figure 12: Extra oral teratoma (Epignathus) with intraoral extension.

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