Induction Chemotherapy with Docetaxel, Cisplatin and 5-Fluorouracil (TPF) Followed by Chemoradiotherapy for Locally Advanced Head and Neck Cancer: Can It Achieve Its Potential?

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for

researchers?

A: Excellent

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Very good

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Very good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Very good

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Very good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Very good

Comments:

The observations of the study are appropriately examined and clarified in the Discussion. Increased overall survival rates and larynx preservation rates have proved the potential of induction chemotherapy with docetaxel, cisplatin and 5-fluorouracil (TPF) and subsequent chemoradiotherapy to treat locally advanced head and neck cancer (LAHNC) patients. The limitations are properly addressed in this section. Further research is required to validate the findings of this study.

Literature

Q: Does the author utilize relevant literature?

A: Very good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Very good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Very good

Writing style

Q: Is it clear and understandable?

A: Good

Further comments on the paper

Comments: This single-center retrospective review, involving 108 patients with locally advanced head and neck cancer (LAHNC), states that induction chemotherapy with docetaxel, cisplatin and 5-fluorouracil (TPF) is one of the optimal treatment strategies for LAHNC patients. Although induction chemotherapy followed by chemoradiotherapy has achieved higher larynx preservation rates and prolongs overall survival rates, the toxicity-related concern is still unresolved. Delay and dose reduction of TPF and chemoradiotherapy may reduce the efficiency of the treatment. The implementation of minimal delay or dose reduction of TPF induction and subsequent chemoradiotherapy in future trials may have a probability to prove its superiority over chemoradiotherapy alone in LAHNC treatment.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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Science Repository Team