Non-Small Cell Lung Cancer; Review of Mutations and Tyrosine Kinase Inhibitors

Review Data

Q: Is the topic relevant to the journal's area of interest? Is it contemporary and interesting for

researchers?

A: Very good

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Excellent

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Very good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Very good

Tools and Methods

Q: Are the methods the author uses adequate and well used?

A: Good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Very good

Comments:

This review article presents a short review of the common mutations and tyrosine kinase inhibitors (TKIs) involved in non-small cell lung cancer (NSCLC). The review is well supported with briefly explained tables. In recent years, an increasing number of lung cancers have been observed in people who have never smoked tobacco (LCINS). The Discussion section summarizes from the results of the review in brief the various treatment options available and how these affect the prognosis at different stages of non-small cell lung cancer. It further presents a new mutation that is rare in itself and is the first case to be reported with non-small cell cancer. In Conclusion, the review aptly emphasizes on the need for genetic testing in all patients with lung cancer as well as the importance of customizing treatments to each individual patient based on age, comorbidities, and mutations.

Literature

Q: Does the author utilize relevant literature?

A: Very good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Very good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Very good

Writing style

Q: Is it clear and understandable?

A: Very good

Further comments on the paper

Comments: This article reviews the various mutations seen commonly in non-small cell lung

cancer (NSCLC) and the tyrosine kinase inhibitors that are more readily used in the management. The review holds significance as it reports the first known case of checkpoint mutation seen in a patient with NSCLC and summarizes the common mutations along with targeted therapy with tyrosine kinase inhibitors. It presents the case report of a patient who was a lifetime nonsmoker and was found to have a rare CHEK2 mutation with non-small cell lung cancer.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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Science Repository Team