Ultrasonic Activation of the Sonosensitizer Fimaporfin Enhances the Efficacy of Chemotherapy: An In Vitro Study on Rat Glioma Cells

Review Data

Purpose and Significance of Study: This study showed that focused ultrasound activation of fimaporfin together with bleomycin significantly inhibits the viability of rat glioma monolayers in vitro. This shows promise for alternative treatment of a number of conditions from cancer to bacterial infections.

 

Fit with Scope of Journal: The manuscript is of very high interest for the journal Clinical Oncology and Research.

The manuscript contains some very minor errors (already corrected in the galley proof, except the highlighted one, which requires the author’s attention), which are listed below –

 

The common errors are –

·       “disulphonate” must be replaced with “disulfonate” in all places to maintain consistency.

·       Omission of “.”, e.g., after “adhere” in the 1^st sentence of Fluorescence microscopy of TPCS_2a intra-cellular distribution in the Materials and Methods, before “however” in the 2^nd paragraph of Discussion, and so on.

·       Omission of “,”, e.g., after “therapy” in the 1^st sentence of the Abstract, after “(<20 nm)” in the 7^th sentence of the 1^st paragraph of the Introduction, and so on.

·       Omission of “the”, e.g., before “treatment” in the 1^st sentence of the Abstract, before “pure” in the 2^nd sentence of Fluorescence microscopy of TPCS_2a intra-cellular distribution in the Materials and Methods, and so on.

·       Omission of “,” after “i.e.” and “e.g.” and “.” After “vs”.

·       Words like “light-activated” and “glass-bottomed” must be hyphenated.

·       “which” must be replaced with “that” in some places, e.g., in the 3^rd sentence of the Abstract, in the 2^nd sentence of the 2^nd paragraph of the SCI mediated BLM effects on F98 cells in the Results, and so on.

The other errors are –

In the Materials and Methods –

  Under Fluorescence microscopy of TPCS_2a intra-cellular distribution –

·       “fluorescence” is misspelled.

  Under Glioma cell growth viability assays –

·       In the 4^th sentence, “;” after “either” must be replaced with “of the following:”.

  Under BLM and BLM +FUS toxicity –

·       In the 1^st sentence, “were” must be replaced with “was”.

  Under Statistical analysis –

  In the paragraph below the formula –

·       In the 1^st sentence, “SFⁱ” must be replaced with “SF”.

In the Conclusion –

·       In the 1^st sentence, “fold” must be replaced with “folds”.

Author Info

Anders Høgset Henry Hirschberg Jimmy Nguyen Le Kristian Berg Odrun A Gederaas Steen J Madsen

Corresponding Author

Jimmy Nguyen Le
Beckman Laser Institute and Medical Clinic, University of California, Irvine, California, USA

Article Info

Article Type

Research Article

Publication history

Received: Tue 05, May 2020
Accepted: Mon 18, May 2020
Published: Fri 29, May 2020

Copyright

© 2023 Jimmy Nguyen Le. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.COR.2020.05.10