Automated Quantification of CD44, c-MET, EGFR, MTOR, and GLUT1 Expression in Head and Neck Squamous Cell Carcinoma: The Impact of p16 Status and Response to Chemoradiation

Review Data

The manuscript entitled “Automated quantification of CD44, c-MET, EGFR, MTOR, and GLUT1 expression in head and neck squamous cell carcinoma: The impact of p16 status and response to chemoradiation” is an interesting study.

 

Purpose and Significance of Study: This study involved the automated quantification of the expression of several biomarkers namely CD44, c-MET, MTOR, EGFR, and GLUT1 in head and neck cancer specimens from patients who underwent definitive chemoradiation. This is the first study that used automated analysis to interrogate the potential prognostic significance of biomarkers using a tissue microarray and biomarkers which had previously been shown to have significant prognostic value using semi-quantitative visual inspection.

 

The manuscript is very well-written. Some very minor errors (already corrected in the galley proof) are listed below –

 

The common errors are –

·       Omission of articles, e.g., “the” before “representative” in the 2^nd sentence of Patient selection and generation of TMA in the Materials and Methods, before “patients” in the 4^th sentence of Biomarkers and clinical outcomes in the Results, and so on.

·       Omission of “,”, e.g., after “general” in the last sentence of the 2^nd paragraph in the Introduction, after “pathologist” in the 2^nd sentence of Patient selection and generation of TMA in the Materials and Methods, and so on.

·       Usage of singular instead of plural number, e.g., in the 5^th sentence of the 3^rd paragraph and in the last paragraph of the Abstract, “expression” must be replaced with “expressions”, in the last sentence of the last paragraph of the Introduction, “biomarker” after “quantification of” must be replaced with “biomarkers”, and so on.

·       “Intensity-modulated” and “high-resolution” must be hyphenated.

·       “e.g.” and “i.e.” must be followed by “,”, and “etc” must be followed by “.”.

The others are –

In the Materials and Methods –

  Under Immunohistochemistry –

·       In the last sentence, “chromogen” is misspelled.

In the Results –

  Under Biomarker analysis –

  In the last paragraph –

·       In the 1^st sentence, “and” after “;” must be removed.

  Under Biomarkers and clinical outcomes –

  In the 4^th paragraph –

·       In the 1^st sentence, “are” must be replaced with “is”.

In the Discussion –

  In the 1^st paragraph –

·       In the 10^th sentence, “median” after “103” must be removed as it is repeated.

The manuscript is therefore recommended for publication in Clinical Oncology and Research.

Author Info

Jessica D. Arden Thomas J. Quinn Thomas G. Wilson Alaa Hanna Kenneth Barker Rohan Deraniyagala Andrew M. Baschnagel George Wilson

Corresponding Author

George Wilson
Department of Radiation Oncology, Beaumont Health, Royal Oak, Michigan, USA

Article Info

Article Type

Research Article

Publication history

Received: Wed 13, May 2020
Accepted: Mon 01, Jun 2020
Published: Fri 12, Jun 2020

Copyright

© 2023 George Wilson. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.COR.2020.06.03